SUPPORT AND RESOURCES FOR YOUR PATIENTS

We offer resources and support to help your patients with FASENRA. Our patient starter brochure provides an overview and can get your patients on the right path forward.

Download Patient Starter Brochure

Pathway to getting patients started with FASENRA

Share this video with your patients when you are ready to start them on FASENRA. It includes information on insurance coverage, obtaining their prescription, administration, and more.

Pathway to getting patients started with FASENRA

Share this video with your patients when you are ready to start them on FASENRA. It includes information on insurance coverage, obtaining their prescription, administration, and more.

Support for at-home patient self-injection

Share this self-injection video with your patients

Share this self-injection video with your patients

These instructions will show your patients how to self-administer FASENRA Pen at home.

Download Instructions for Use

Share this self-injection video with your patients

These instructions will show your patients how to self-administer FASENRA Pen at home.

Download Instructions for Use

Request the following to help make sure your patients have what they need for self-injection:

Disposal Container Icon01

A sharps disposal container, to safely
dispose of the FASENRA Pen

Insulated Travel Bag Icon02

An insulated travel bag, to
take their FASENRA Pen anywhere

Practice Demo Pen Icon03

A demo pen, so
they can practice

Practice Demo Pen Icon

Patient Injection Tracker

Keep track of injections administered to your FASENRA patients.

Download Injection Tracker

ADDITIONAL SUPPORT

Phone Icon Representing Get FASENRA Supplies

Get Supplies Now

Call 1-833-360-HELP (4357) Monday through Friday, 8 AM to 6 PM ETor have your patients join FASENRA 360 at FASENRASignUp.com.

Patient Icon

Reimbursement Counselors

Our specialized personal reimbursement counselors from AstraZeneca can help your patient by reviewing their insurance benefits and finding affordability programs that are right for them.

If you have any questions, call 1-833-360-HELP (4357), Monday through Friday, 8 AM to 6 PM ET.

Calendar Icon

Dose Reminder Program

FASENRA 360 dose reminders help keep your patients on schedule with their treatment. We can provide the dose reminders via text, email, or on their calendar.

Patients can sign up by calling 1-833-360-HELP (4357), Monday through Friday, 8 AM to 6 PM ET. Patients can also sign up online.

Enroll Online

Pathway to getting patients started with FASENRA

Share this video with your patients when you are ready to start them on FASENRA. It includes information on insurance coverage, obtaining their prescription, administration, and more.

IMPORTANT SAFETY INFORMATION -

CONTRAINDICATIONS

Known hypersensitivity to benralizumab or excipients.

WARNINGS AND PRECAUTIONS

Hypersensitivity Reactions

Hypersensitivity reactions (eg, anaphylaxis, angioedema, urticaria, rash) have occurred after administration of FASENRA. These reactions generally occur within hours of administration, but in some instances have a delayed onset (ie, days). Discontinue in the event of a hypersensitivity reaction.

Acute Asthma Symptoms or Deteriorating Disease

FASENRA should not be used to treat acute asthma symptoms, acute exacerbations, or acute bronchospasm.

Reduction of Corticosteroid Dosage

Do not discontinue systemic or inhaled corticosteroids abruptly upon initiation of therapy with FASENRA. Reductions in corticosteroid dose, if appropriate, should be gradual and performed under the direct supervision of a physician. Reduction in corticosteroid dose may be associated with systemic withdrawal symptoms and/or unmask conditions previously suppressed by systemic corticosteroid therapy.

Parasitic (Helminth) Infection

It is unknown if FASENRA will influence a patient’s response against helminth infections. Treat patients with pre-existing helminth infections before initiating therapy with FASENRA. If patients become infected while receiving FASENRA and do not respond to anti-helminth treatment, discontinue FASENRA until infection resolves.

ADVERSE REACTIONS

The most common adverse reactions (incidence ≥ 5%):

  • Asthma: headache, pharyngitis
  • EGPA: headache
  • HES: headache, hypersensitivity reactions, influenza-like illness

Injection site reactions (eg, pain, erythema, pruritus, papule) occurred at a rate of 2.2% in patients treated with FASENRA compared with 1.9% in patients treated with placebo in asthma exacerbation studies.

USE IN SPECIFIC POPULATIONS

The data on pregnancy exposure from the clinical trials are insufficient to inform on drug-associated risk. Monoclonal antibodies such as benralizumab are transported across the placenta during the third trimester of pregnancy; therefore, potential effects on a fetus are likely to be greater during the third trimester of pregnancy.

Pediatrics: The safety and efficacy of FASENRA in asthma patients less than 6 and in EGPA patients less than 18 years of age has not been established.

INDICATIONS

FASENRA is indicated for:

  • the add-on maintenance treatment of patients with severe asthma aged 6 years and older and with an eosinophilic phenotype. FASENRA is not indicated for the relief of acute bronchospasm or status asthmaticus
  • the treatment of adult patients with eosinophilic granulomatosis with polyangiitis (EGPA)
  • the treatment of adult and adolescent patients aged 12 years and older with hypereosinophilic syndrome (HES) without an identifiable non-hematologic secondary cause

Please read full Prescribing Information, including Patient Information.

Please read full Prescribing Information, including Patient Information.

You may report side effects related to AstraZeneca products .

IMPORTANT SAFETY INFORMATION

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References

Reference

1. FASENRA® (benralizumab) [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2026. 2. Wechsler ME, Nair P, Terrier B, et al; MANDARA Study Group. Benralizumab versus mepolizumab for eosinophilic granulomatosis with polyangiitis. N Engl J Med. 2024;390(10):911-921.

1. Fagni F, Bello F, Emmi G. Eosinophilic granulomatosis with polyangiitis: dissecting the pathophysiology. Front Med (Lausanne). 2021;8:627776. 2. Khoury P, Grayson PC, Klion AD. Eosinophils in vasculitis: characteristics and roles in pathogenesis. Nat Rev Rheumatol. 2014;10(8):474-483. 3. Emmi G, Bettiol A, Gelain E, et al. Evidence-based guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis. Nat Rev Rheumatol. 2023;19(6):378-393. 4. Matucci A, Vivarelli E, Perlato M, et al. EGPA phenotyping: not only ANCA, but also eosinophils. Biomedicines. 2023;11(3):776. 5. Furuta S, Iwamoto T, Nakajima H. Update on eosinophilic granulomatosis with polyangiitis. Allergol Int. 2019;68(4):430-436. 6. Chakraborty RK, Rout P. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025. Updated September 19, 2024. Accessed July 8, 2025. https://www.ncbi.nlm.nih.gov/books/NBK537099/ 7. Baldini C, Talarico R, Della Rossa A, Bombardieri S. Clinical manifestations and treatment of Churg-Strauss syndrome. Rheum Dis Clin North Am. 2010;36(3):527-543.

1. FASENRA® (benralizumab) [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; September 2024.

1. FASENRA® (benralizumab) [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; September 2024. 2. Wechsler ME, Nair P, Terrier B, et al; MANDARA Study
Group. Benralizumab versus mepolizumab for eosinophilic granulomatosis with polyangiitis. N Engl J Med. 2024;390(10):911-921. 3. Merkel PA, Nair PK, Khalidi N, et al; MANDARA Study Group. Two-year efficacy and safety of anti-interleukin-5/receptor therapy for eosinophilic granulomatosis with polyangiitis. Ann Rheum Dis. 2025;84(11):1888-1899. doi:10.1016/j.ard.2025.06.2131 4. Merkel PA, Nair PK, Khalidi N, et al; MANDARA Study Group. Two-year efficacy and safety of anti-interleukin-5/receptor therapy for eosinophilic granulomatosis with polyangiitis. Ann Rheum Dis. 2025;(suppl). doi:10.1016/j.ard.2025.06.2131

1. Grayson PC, Ponte C, Suppiah R, et al. 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for eosinophilic granulomatosis with polyangiitis. Ann Rheum Dis. 2022;81(3):309-314. 2. Jennette JC, Falk RJ, Bacon PA, et al. 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides. Arthritis Rheum. 2013;65(1):1-11. 3. Furuta S, Iwamoto T, Nakajima H. Update on eosinophilic granulomatosis with polyangiitis. Allergol Int. 2019;68(4):430-436. 4. Chakraborty RK, Rout P. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025. Updated September 19, 2024. Accessed July 8, 2025. https://www.ncbi.nlm.nih.gov/books/NBK537099/ 5. Trivioli G, Terrier B, Vaglio A. Eosinophilic granulomatosis with polyangiitis: understanding the disease and its management. Rheumatology (Oxford). 2020;59(suppl 3):iii84-iii94.

1. FASENRA® (benralizumab) [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; September 2024. 2. Wechsler ME, Nair P, Terrier B, et al; MANDARA Study Group. Benralizumab versus mepolizumab for eosinophilic granulomatosis with polyangiitis. N Engl J Med. 2024;390(10):911-921. 3. Wechsler ME, Nair P, Terrier B, et al; MANDARA Study Group. Benralizumab versus mepolizumab for eosinophilic granulomatosis with polyangiitis. N Engl J Med. 2024;390(10)(suppl):1-46. 4.
Merkel PA, Nair PK, Khalidi N, et al; MANDARA Study Group. Two-year efficacy and safety of anti-interleukin-5/receptor therapy for eosinophilic granulomatosis with polyangiitis. Ann Rheum Dis. 2025;84(11):1888-1899. doi:10.1016/j.ard.2025.06.2131

1. FASENRA® (benralizumab) [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; September 2024. 2. Wechsler ME, Nair P, Terrier B, et al; MANDARA Study Group. Benralizumab versus mepolizumab for eosinophilic granulomatosis with polyangiitis. N Engl J Med. 2024;390(10):911-921. 3. Merkel PA, Nair PK, Khalidi N, et al; MANDARA Study Group. Two-year efficacy and safety of anti-interleukin-5/receptor therapy for eosinophilic granulomatosis with polyangiitis. Ann Rheum Dis. 2025;84(11):1888-1899. doi:10.1016/j.ard.2025.06.2131 4. Wechsler ME, Nair P, Terrier B, et al; MANDARA Study Group. Benralizumab versus mepolizumab for eosinophilic granulomatosis with polyangiitis. N Engl J Med. 2024;390(10)(suppl):1-46.

1. FASENRA® (benralizumab) [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; September 2024. 2. Wechsler ME, Nair P, Terrier B, et al; MANDARA Study Group. Benralizumab versus mepolizumab for eosinophilic granulomatosis with polyangiitis. N Engl J Med. 2024;390(10):911-921. 3. Wechsler ME, Nair P, Terrier B, et al; MANDARA Study Group. Benralizumab versus mepolizumab for eosinophilic granulomatosis with polyangiitis. N Engl J Med. 2024;390(10)(suppl):1-46.

1. FASENRA® (benralizumab) [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; September 2024. 2. Wechsler ME, Nair P, Terrier B, et al; MANDARA Study Group. Benralizumab versus mepolizumab for eosinophilic granulomatosis with polyangiitis. N Engl J Med. 2024;390(10):911-921. 3. Data on File, US-103275, AZPLP. 4. Merkel PA, Nair PK, Khalidi N, et al; MANDARA Study Group. Two-year efficacy and safety of anti-interleukin-5/receptor therapy for eosinophilic granulomatosis with polyangiitis. Ann Rheum Dis. 2025;84(11):1888-1899. doi:10.1016/j.ard.2025.06.2131

1. FASENRA® (benralizumab) [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; September 2024. 2. Wechsler ME, Nair P, Terrier B, et al; MANDARA Study Group. Benralizumab versus mepolizumab for eosinophilic granulomatosis with polyangiitis. N Engl J Med. 2024;390(10):911-921. 3. Nucala® (mepolizumab) [package insert]. Philadelphia, PA: GlaxoSmithKline LLC; August 2025.